{"id":10470,"date":"2024-07-08T08:59:29","date_gmt":"2024-07-07T23:59:29","guid":{"rendered":"https:\/\/www.konan-u.ac.jp\/front\/?page_id=10470"},"modified":"2024-07-08T08:59:31","modified_gmt":"2024-07-07T23:59:31","slug":"interview-22","status":"publish","type":"page","link":"https:\/\/www.konan-u.ac.jp\/front\/researchers\/interview-22","title":{"rendered":"DNA\u306f\u904b\u547d\u306e\u76f8\u624b\u3068\u51fa\u4f1a\u3044\u3001\u7d50\u3070\u308c\u308b\uff01\u2212Undruggable\u3092Druggable\u306b\u3059\u308b\u6838\u9178\u533b\u85ac\u54c1\u306e\u958b\u767a\u2212\u3002\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u30b5\u30a4\u30a8\u30f3\u30b9\u5b66\u90e8 \u751f\u547d\u5316\u5b66\u79d1 \u5ddd\u4e0a \u7d14\u53f8 \uff08\u6838\u9178\u5316\u5b66 \/ \u7269\u7406\u7cfb\u85ac\u5b66\uff09"},"content":{"rendered":"\n

\u85ac\u5b66\u306e\u5c02\u9580\u5bb6\u3067\u3001\u6838\u9178\u533b\u85ac\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u308b\u5ddd\u4e0a\u7d14\u53f8\u6559\u6388\u306b\u304a\u8a71\u3092\u4f3a\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

About Me ( KAWAKAMI Junji )<\/strong><\/h2>\n\n\n\n

\u7814\u7a76\u5ba4\u540d\u306f\u907a\u4f1d\u5b50\u85ac\u5b66\u7814\u7a76\u5ba4\u3067\u3001\u5c02\u9580\u5206\u91ce\u306f\u907a\u4f1d\u60c5\u5831\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u5b66\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u306f\u6838\u9178\uff08DNA\u3084RNA\uff09\u306e\u591a\u69d8\u306a\u69cb\u9020\u5f62\u6210\u3068\u305d\u306e\u6027\u8cea\u3092\u7814\u7a76\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u79c1\u304c\u5927\u5b66\u9662\u306e\u4fee\u58eb\u8ab2\u7a0b2\u5e74\u306e\u6642\u306b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9DNA\/RNA\u7814\u7a76\u4f1a\u304c\u767a\u8db3\u3057\u3001DNA\u3084RNA\u3092\u85ac\u3068\u3057\u3066\u4f7f\u3048\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u30a2\u30a4\u30c7\u30a2\u304c\u5b9f\u7528\u5316\u306b\u5411\u304b\u3063\u3066\u4e00\u6b69\u8e0f\u307f\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3092\u6a5f\u306b\u3001\u7814\u7a76\u4f1a\u306e\u4ee3\u8868\u3092\u52d9\u3081\u3066\u304a\u3089\u308c\u305f\u5148\u751f\u306e\u9580\u4e0b\u306b\u52a0\u308f\u308a\u3001\u535a\u58eb\u8ab2\u7a0b\u3067\u306f\u73fe\u5728\u306e\u6838\u9178\u533b\u85ac\u3078\u7e6b\u304c\u308b\u7814\u7a76\u3092\u59cb\u3081\u307e\u3057\u305f\u3002\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9DNA\/RNA\u7814\u7a76\u4f1a\u304c\u767a\u5c55\u7684\u306b\u65e5\u672c\u6838\u9178\u533b\u85ac\u5b66\u4f1a\u3078\u6539\u7d44\u3057\u305f2015\u5e74\u304b\u3089\u5b66\u4f1a\u306e\u4e8b\u52d9\u5c40\u9577\u3092\u4efb\u305b\u3066\u9802\u3044\u3066\u304a\u308a\u3001\u5b66\u751f\u6642\u4ee3\u306b\u82bd\u751f\u3048\u305f\u8208\u5473\u3068\u6df1\u3044\u95a2\u308f\u308a\u3092\u6301\u3061\u7d9a\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u3066\u3044\u308b\u5e78\u305b\u3092\u611f\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Research<\/strong><\/h2>\n\n\n\n

An antisense DNA binds only to its destined partner.<\/h3>\n\n\n\n

\u3053\u308c\u307e\u3067\u306e\u533b\u85ac\u54c1\u306f\u75c5\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3057\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3057\u3066\u6a5f\u80fd\u5236\u5fa1\u3059\u308b\u5316\u5408\u7269\u304c\u63a2\u7d22\u3055\u308c\u3001\u5229\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30d2\u30c8\u306e\u4f53\u5185\u306b\u3042\u308b\u6570\u4e07\u7a2e\u985e\u3082\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e2d\u304b\u3089\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3060\u3051\u7d50\u5408\u3059\u308b\u5316\u5408\u7269\u304c\u898b\u3064\u304b\u308b\u3053\u3068\u306f\u7a00\u3067\u3042\u308a\u3001\u901a\u5e38\u306f\u76ee\u7684\u4ee5\u5916\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3082\u7d50\u5408\u3057\u3066\u3057\u307e\u3044\u526f\u4f5c\u7528\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u578b\u306e\u6838\u9178\u533b\u85ac\u54c1\u306f\u3001\u6838\u9178\u306e\u53b3\u5bc6\u306a\u76f8\u88dc\u9396\u8a8d\u8b58\u80fd\u3092\u5229\u7528\u3057\u3066\u3001\u4e3b\u306bmRNA\uff08\u30bb\u30f3\u30b9\uff09\u306b\u7d50\u5408\u3057\u3001\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u5206\u5b50\u3067\u3059\u3002\u6838\u9178\u533b\u85ac\u54c1\u306f\u30bb\u30f3\u30c8\u30e9\u30eb\u30c9\u30b0\u30de\u306e\u4e0a\u6d41\u306b\u3042\u308b\u907a\u4f1d\u60c5\u5831\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u5171\u901a\u6027\u306e\u9ad8\u3044\u958b\u767a\u30b9\u30c8\u30e9\u30c6\u30b8\u30fc\u3067\u3042\u3089\u3086\u308b\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3059\u308b\u85ac\u5264\u3092\u5275\u308a\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u4e00\u672c\u9396\u306eDNA\u3084RNA\u304c\u81ea\u5206\u306e\u904b\u547d\u306e\u76f8\u624b\uff08\u76f8\u88dc\u9396\u6838\u9178\uff09\u3068\u3060\u3051\u7d50\u3070\u308c\u3066\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u6027\u8cea\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u65e2\u5b58\u306e\u533b\u85ac\u54c1\u3088\u308a\u3082\u683c\u6bb5\u306b\u526f\u4f5c\u7528\u304c\u5c11\u306a\u3044\u533b\u85ac\u54c1\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

Oligonucleotide Therapeutics make “undruggable” druggable.<\/h3>\n\n\n\n

\u3053\u306e\u3088\u3046\u306a\u65e2\u5b58\u306e\u533b\u85ac\u54c1\u3068\u5168\u304f\u7570\u306a\u308b\u7279\u6027\u3068\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u3082\u3064\u6838\u9178\u533b\u85ac\u54c1\u306f\u3001\u3053\u308c\u307e\u3067\u300cundruggable\uff08\u5275\u85ac\u4e0d\u53ef\u80fd\uff09\u300d\u3068\u547c\u3070\u308c\u3066\u304d\u305f\u3042\u308a\u3068\u3042\u3089\u3086\u308b\u96e3\u6cbb\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u3092\u53ef\u80fd\u306b\u3059\u308b\u3068\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u975e\u5e38\u306b\u9ad8\u4fa1\u3067\u3042\u308b\u3053\u3068\u304c\u5927\u304d\u306a\u30cd\u30c3\u30af\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u6570\u5e74\u524d\u306b\u627f\u8a8d\u3055\u308c\u305f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u6838\u9178\u533b\u85ac\u54c1\u306b\u306f\u3001\u4e00\u5186\u7389\u3068\u540c\u30581g\u30677\u51044\u5343\u4e07\u5186\u3082\u306e\u5024\u6bb5\u304c\u3064\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u533b\u85ac\u54c1\u306e\u4fa1\u683c\u306b\u591a\u984d\u306e\u7814\u7a76\u958b\u767a\u8cbb\u7528\u304c\u4e0a\u4e57\u305b\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5927\u304d\u306a\u8981\u56e0\u3067\u3059\u3002\u6211\u3005\u306f\u6838\u9178\u533b\u85ac\u54c1\u304c\u3069\u306e\u3088\u3046\u306a\u5869\u57fa\u914d\u5217\u3092\u3082\u3061\u3001\u3069\u306e\u3088\u3046\u306a\u5316\u5b66\u4fee\u98fe\u3092\u3069\u3053\u306b\u65bd\u305b\u3070\u6709\u52b9\u306a\u533b\u85ac\u54c1\u3068\u306a\u308a\u5f97\u308b\u304b\u3092\u3001\u8a66\u884c\u932f\u8aa4\u305b\u305a\u3068\u3082\u4e88\u6e2c\u3067\u304d\u308b\u624b\u6cd5\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u6211\u3005\u306e\u7814\u7a76\u306e\u5148\u306b\u306f\u3001\u3053\u308c\u307e\u3067\u6cbb\u7642\u306e\u624b\u6bb5\u304c\u306a\u304f\u7d76\u671b\u306e\u6df5\u306b\u3042\u3063\u305f\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u306e\u3082\u3068\u306b\u3001\u5b89\u4fa1\u306a\u6838\u9178\u533b\u85ac\u54c1\u304c\u5c4a\u304f\u672a\u6765\u304c\u5f85\u3063\u3066\u3044\u308b\u3068\u4fe1\u3058\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

KONAN\u2019s Value<\/strong><\/h2>\n\n\n\n
\n
\n

\u7532\u5357\u5927\u5b66\u306f\u300c\u65e7\u5236\u9ad8\u6821\u300d\u300c\u6587\u7cfb\u300d\u306e\u30a4\u30e1\u30fc\u30b8\u304c\u5f37\u3044\u3067\u3059\u304c\u3001\u7d4c\u55b6\u8005\u306e\u5b50\u606f\u304c\u591a\u304f\u5de3\u7acb\u3063\u305f\u3068\u3044\u3046\u6b74\u53f2\u306f\u7406\u7cfb\u306e\u4f01\u696d\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u6838\u9178\u533b\u85ac\u54c1\u306e\u54c1\u8cea\u57fa\u6e96\u3092\u8a2d\u5b9a\u3059\u308b\u3068\u3044\u3046\u56fd\u5bb6\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306730\u793e\u3092\u8d85\u3048\u308b\u7406\u7cfb\u4f01\u696d\u3068\u3054\u4e00\u7dd2\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u7532\u5357\u5927\u5b66\u3068\u95a2\u4fc2\u306e\u3042\u308b\u4f01\u696d\u304c\u591a\u3044\u3053\u3068\u306b\u9a5a\u304b\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u30b5\u30a4\u30a8\u30f3\u30b9\u5b66\u90e8\u306e\u3042\u308b\u30dd\u30fc\u30c8\u30a2\u30a4\u30e9\u30f3\u30c9\u306f\u533b\u7642\u7523\u696d\u90fd\u5e02\u3068\u3057\u3066\u7406\u7cfb\u4f01\u696d\u304c\u591a\u304f\u96c6\u7a4d\u3057\u3001\u300c\u3054\u8fd1\u6240\u3055\u3093\u300d\u3068\u5171\u540c\u7814\u7a76\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u57a3\u6839\u306e\u4f4e\u3044\u74b0\u5883\u304c\u5b9f\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u5b66\u751f\u3055\u3093\u304c\u6e2c\u5b9a\u8a66\u6599\u3092\u3076\u3089\u4e0b\u3052\u3066\u5171\u540c\u7814\u7a76\u4f01\u696d\u306e\u7814\u7a76\u6240\u306b\u5f92\u6b69\u3067\u5411\u304b\u3046\u3068\u3044\u3046\u5149\u666f\u306f\u3001\u56fd\u5185\u3092\u63a2\u3057\u3066\u3082\u4ed6\u6240\u3067\u306f\u306a\u304b\u306a\u304b\u898b\u3089\u308c\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Private<\/strong><\/h2>\n\n\n\n
\n
\n

\u82e5\u3044\u9803\u306f\u5927\u578b\u30d0\u30a4\u30af\u3067\u306e\u30c4\u30fc\u30ea\u30f3\u30b0\u304c\u597d\u304d\u3067\u3057\u305f\u304c\u3001\u6700\u8fd1\u3067\u306f\u4f11\u307f\u306e\u65e5\u306f\u6587\u623f\u5177\u53ce\u96c6\u306b\u6642\u9593\u3092\u4f7f\u3046\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u30bf\u30fc\u30b2\u30c3\u30c8\u306f\u4e3b\u306b\u53e4\u3044\u925b\u7b46\u3068\u53e4\u3044\u4e07\u5e74\u7b46\u3002\u6614\u304b\u3089\u55b6\u696d\u3057\u3066\u3044\u308b\u3068\u304a\u307c\u3057\u304d\u4f47\u307e\u3044\u306e\u6587\u623f\u5177\u5c4b\u3055\u3093\u3092\u63a2\u3057\u3066\u6b69\u304d\u3001\u30c7\u30c3\u30c9\u30b9\u30c8\u30c3\u30af\u3092\u51fa\u3057\u3066\u3082\u3089\u3063\u3066\u5b9d\u63a2\u3057\u3092\u3057\u3066\u3044\u308b\u3068\u3001\u3042\u3063\u3068\u3044\u3046\u9593\u306b\u6642\u9593\u304c\u7d4c\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u30aa\u30fc\u30af\u30b7\u30e7\u30f3\u30b5\u30a4\u30c8\u30671\u672c\u6570\u5343\u5186\u3059\u308b\u925b\u7b46\u3092\u843d\u672d\u3057\u3066\u306f\u3001\u300c\u8ab0\u3082\u3053\u306e\u53e4\u307c\u3051\u305f\u925b\u7b46\u306b\u4fa1\u5024\u304c\u3042\u308b\u3068\u306f\u601d\u308f\u306a\u3044\u3060\u308d\u3046\u306a\u300d\u3068\u307b\u304f\u305d\u7b11\u307f\u3064\u3064\u3001\u666e\u901a\u306b\u524a\u3063\u3066\u4f7f\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u4e07\u5e74\u7b46\u306e\u30a4\u30f3\u30af\u306f\u8272\u7d20\u3092\u8abf\u5408\u3057\u3066\u597d\u307f\u306e\u8272\u3092\u81ea\u4f5c\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Profile<\/strong><\/h2>\n\n\n\n
\n
\n
\"\"<\/figure>\n\n\n\n

\u30d5\u30ed\u30f3\u30c6\u30a3\u30a2\u30b5\u30a4\u30a8\u30f3\u30b9\u5b66\u90e8 \u751f\u547d\u5316\u5b66\u79d1 \u6559\u6388<\/p><\/p>\n\n\n\n

\u5ddd\u4e0a \u7d14\u53f8<\/p>\n\n\n\n

KAWAKAMI Junji<\/p>\n<\/div>\n\n\n\n

\n

\u5c02\u9580\u9818\u57df<\/strong>
\u6838\u9178\u5316\u5b66\u3001\u7269\u7406\u7cfb\u85ac\u5b66<\/p>\n\n\n\n

\u30ad\u30e3\u30ea\u30a2<\/strong>
\u5927\u962a\u5927\u5b66 \u85ac\u5b66\u90e8\u3000\u5352
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\u7532\u5357\u5927\u5b66 \u6838\u9178\u533b\u85ac\u7814\u7a76\u6240 \u6240\u9577<\/p>\n\n\n\n

\u6240\u5c5e\u5b66\u4f1a<\/strong>
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RNA Society<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"\u85ac\u5b66\u306e\u5c02\u9580\u5bb6\u3067\u3001\u6838\u9178\u533b\u85ac\u306b\u3064\u3044\u3066\u7814\u7a76\u3057\u3066\u3044\u308b\u5ddd\u4e0a\u7d14\u53f8\u6559\u6388\u306b\u304a\u8a71\u3092\u4f3a\u3044\u307e\u3057\u305f\u3002 About Me ( KAWAKAMI Junji ) \u7814\u7a76\u5ba4\u540d\u306f\u907a\u4f1d\u5b50\u85ac\u5b66\u7814\u7a76\u5ba4\u3067\u3001\u5c02\u9580\u5206\u91ce\u306f\u907a\u4f1d\u60c5\u5831\u3092\u6a19\u7684\u3068\u3057\u305f\u85ac\u5b66\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u306f\u6838\u9178\uff08","protected":false},"author":1,"featured_media":10471,"parent":8715,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-interview.php","meta":{"footnotes":"","_expiration-date-status":"","_expiration-date":1721001175,"_expiration-date-type":"draft","_expiration-date-categories":[],"_expiration-date-options":[]},"acf":[],"_links":{"self":[{"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/pages\/10470"}],"collection":[{"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/comments?post=10470"}],"version-history":[{"count":2,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/pages\/10470\/revisions"}],"predecessor-version":[{"id":10477,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/pages\/10470\/revisions\/10477"}],"up":[{"embeddable":true,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/pages\/8715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/media\/10471"}],"wp:attachment":[{"href":"https:\/\/www.konan-u.ac.jp\/front\/wp-json\/wp\/v2\/media?parent=10470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}