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原著論文・総説・著作 プロシーディング 学会 特許など


2022 2021
2020 2018 2017 2016 2015 2014 2013 2012 2011
2010 2009 2007 2006 2005 2004 2003


    2022

  1. De Novo Design of a Nanopore for Single-Molecule Detection That Incorporates a Beta-Hairpin Peptide
    Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, Ryuji Kawano
    Nature Nanotechnology, 17, 67-75
    2022/01
    [journal page] [Pubmed]

  2. 先頭へ


    2021

  3. マイクロ波照射による細胞への影響とその応用
    平田桃、川内敬子、西方敬人、中西伸浩、臼井健二*
    日本電磁場エネルギー応用学会論文誌, 5, 38-48
    2021/12
    [Journal page]

  4. De novo design of a nanopore for single-molecule detection that incorporates a beta-hairpin peptide
    Keisuke Shimizu, Batsaikhan Mijiddorj, Masataka Usami, Ikuro Mizoguchi, Shuhei Yoshida, Shiori Akayama, Yoshio Hamada, Akifumi Ohyama, Kenji Usui, Izuru Kawamura, Ryuji Kawano
    Nature Nanotechnology, Online ahead of print
    2021/11
    [Journal page] [Pubmed]

  5. ウォッシャーディスインフェクターのすすぎ排水中に含まれる洗浄剤残留量の測定によるすすぎ性能評価
    三軒隼人、藤田敏、川田原瑠勇、武川公、臼井健二、原田陽滋
    医療機器学, 91, 315-332
    2021/08
    [Journal page]

  6. 総合研究所研究チーム研究
    「生体への影響解析のための電磁波照射装置の開発と開発研究におけるアウトリーチ活動」
    臼井健二*、梅谷智弘
    甲南大学総合研究所叢書, 142, ISSN 2433-5851
    2021/03
    [PDF]

  7. 適用範囲の広い皮膚感作性試験法の開発
    臼井健二*、宮﨑洋、山下邦彦
    Medical Science Digest(北隆館/ニュー・サイエンス社), 47, 226-228
    2021/03
    [Journal page]

  8. Intracellular Mineralization of Gold Nanoparticles Using Gold Ion-Binding Peptides with Cell-Penetrating Ability
    Makoto Ozaki, Shuhei Yoshida, Takaaki Tsuruoka, Kenji Usui*
    Chemical Communications, 57, 725-728 ※裏表紙掲載
    2021/01
    DOI: 10.1039/D0CC06117D
    [Journal page] [Pubmed] [Back cover]

  9. Elemental Composition Control of Gold-Titania Nanocomposites by Site-Specific Mineralization Using Artificial Peptides and DNA
    Makoto Ozaki, Takahito Imai, Takaaki Tsuruoka, Shungo Sakashita, Kin-ya Tomizaki, Kenji Usui*
    Communications Chemistry, 4, 1
    2021/01
    DOI: 10.1038/s42004-020-00440-8
    [Journal page]

  10. 先頭へ


    2020

  11. Effect of Tryptophan Residues on Gold Mineralization by a Gold Reducing Peptide
    Makoto Ozaki, Shuhei Yoshida, Maho Oura, Takaaki Tsuruoka, Kenji Usui*
    RSC Advances, 10, 40461-40466
    2020/11
    DOI: 10.1039/D0RA07098J
    [Journal page] [Pubmed]

  12. Mass Spectrometry-Based Solid Phase Peptide Reaction Assay for Detecting Allergenicity Using an Immobilized Peptide-Conjugating Photo-Cleavable Linker
    Hiroshi Miyazaki,Yasutaka Samejima, Kazuya Iwata, Yuuki Minamino, Shinya Hikida, Hideto Ariumi, Hidefumi Ikeda, Yoshio Hamada, Kunihiko Yamashita, Kenji Usui*
    International Journal of Molecular Sciences, 21, 8332
    2020/11
    DOI: 10.3390/ijms21218332
    [Journal page] [Pubmed]

  13. Synthesis of Peptide-Immobilized Magnetic Beads, and Peptide Reactivity Assay for Assessing Skin Sensitization Utilizing Chromophore
    Hiroshi Miyazaki, Hikaru Takaishi, Hidefumi Ikeda, Hideto Ariumi, Yoshio Hamada, Kunihiko Yamashita, Kenji Usui*
    Processes, 8, 1257
    2020/09
    DOI: 10.3390/pr8101257
    [Journal page]

  14. Novel Purification Process for Amyloid Beta Peptide(1-40)
    Kenji Usui*,Shin-ichiro Yokota, Kazuya Iwata, Yoshio Hamada
    Processes, 8, 464 ※表紙掲載
    2020/04
    DOI: 10.3390/pr8040464
    [Journal page] [Cover Story] [Cover]

  15. Development of a Chromophore-Solid Phase Peptide Reaction Assay (C-SPRA) for Assessing Skin Sensitization In Vitro
    Hiroshi Miyazaki, Yoshio Hamada, Hikaru Takaishi, Yuuki Minamino, Hidefumi Ikeda, Hideaki Mekata, Masayuki Takaishi, Kunihiko Yamashita, Kenji Usui*
    Analyst, 145, 3211-3216 ※中裏表紙掲載
    2020/03
    DOI: 10.1039/C9AN02514F
    [Journal page] [Pubmed] [Inside back cover]

  16. 先頭へ


    2018

  17. 第6節 ペプチド固定化樹脂を用いた皮膚感作性試験法の開発
    臼井健二*、宮﨑洋、南野祐槻、濵田芳男、山下邦彦
    皮膚の安全性・有用性評価法, 88-95
    2018/05
    ISBN: 978-4-86104-712-1-3047
    [Journal page]

  18. Channel Current Analysis Estimates the Pore-formation and the Penetration of Transmembrane Peptides
    Yusuke Sekiya, Shungo Sakashita Keisuke Shimizu, Kenji Usui, Ryuji Kawano
    Analyst, 143, 3540-3543
    2018/05
    DOI: 10.1039/C8AN00243F
    [Journal page] [Pubmed] [Inside cover]

  19. Applications of a Novel Biodetection System to Saliva Using Protein Fingerprints with Data Processing
    Yuki Tominaga, Kenji Usui, Akiyoshi Hirata, Hiro-O Ito, Kiyoshi Nokihara
    Bioorganic & Medicinal Chemistry, 26, 3210-3216
    2018/04
    DOI: 10.1016/j.bmc.2018.04.049
    [Journal page] [PubMed]

  20. Editorial: Organic-Inorganic Hybrid Materials and Their Applications
    Kin-ya Tomizaki, Yoshio Hamada, Kenji Usui
    Protein & Peptide Letters, 25, 2-3
    2018/04
    DOI: 10.2174/092986652501180418150844
    [Journal Page] [Pubmed]

  21. Peptides for Silica Precipitation: Amino Acid Sequences for Directing Mineralization
    Makoto Ozaki, Shungo Sakashita, Yoshio Hamada, Kenji Usui*
    Protein & Peptide Letters, 25, 15-24
    2018/04
    DOI: 10.2174/0929866525666171214111007
    [Journal page] [Pubmed]

  22. Modification of the N-Terminus of a Calcium Carbonate Precipitating Peptide Affects Calcium Carbonate Mineralization
    Kenji Usui*, Shin-ichiro Yokota, Makoto Ozaki, Shungo Sakashita, Takahito Imai, Kin-ya Tomizaki
    Protein & Peptide Letters, 25, 42-47
    2018/04
    DOI: 10.2174/0929866525666171221114658
    [Journal page] [Pubmed]

  23. Design of Anti-Alzheimer's Disease Agents Focusing on a Specific Interaction with Target Biomolecules
    Yoshio Hamada*, Kenji Usui
    Neuromethods, 132, 207-228
    2018
    DOI: 10.1007/978-1-4939-7404-7
    [Journal page]
  24. 先頭へ


    2017

  25. 生体分子の挙動解析研究を目標としたマイクロ波照射システムの開発
    ~ペプチドのバイオミネラリゼーションにおけるマイクロ波影響解析をモデルとして~
    臼井健二*、富樫浩行、圓東那津実、尾崎誠、有本米次郎、裏鍛武史、 大沢隆二、皆木幸一、中西伸浩、梅谷智弘*
    日本電磁波エネルギー応用学会論文誌, 17-24
    2017/12
    [Journal page]

  26. DNA G-Wire Formation Using an Artificial Peptide is Controlled by Protease Activity
    Kenji Usui*, Arisa Okada, Shungo Sakashita, Masayuki Shimooka, Takaaki Tsuruoka, Shu-ichi Nakano, Daisuke Miyoshi, Tsukasa Mashima, Masato Katahira, Yoshio Hamada
    Molecules, 22, 1991
    2017/11
    DOI: 10.3390/molecules22111991
    [Journal page] [PubMed]

  27. Non-Covalent Loading of Anti-Cancer Doxorubicin by Modularizable Peptide Self-Assemblies for a Nanoscale Drug Carrier
    Kin-ya Tomizaki*, Kohei Kishioka, Shunsuke Kataoka, Makoto Miyatani, Takuya Ikeda, Mami Komada, Takahito Imai, Kenji Usui*
    Molecules, 22, 1916
    2017/11
    DOI: 10.3390/molecules22111916
    [Journal page] [PubMed]

  28. マイクロビーズ固定化ペプチドを用いたバイオ計測デバイスの開発
    臼井健二*、南野祐槻、宮﨑洋、横田晋一朗、山下邦彦、濵田芳男
    医療・診断をささえるペプチド科学, 298-305
    2017/10
    [Journal page]

  29. Fluorescent and Luminescent Fusion Proteins for Analyses of Amyloid Beta Peptide Aggregation.
    Kenji Usui*, Masayasu Mie, Takashi Andou, Hisakazu Mihara, Eiry Kobatake
    J. Pept. Sci., 23, 659-665
    2017/07
    DOI: 10.1002/psc.3003
    [Journal page] [PubMed]
  30. 先頭へ


    2016

  31. 有機-無機ハイブリッド材料創製を指向した人工ペプチドを用いたミネラリゼーションの制御
    臼井健二*、富﨑欣也
    化学工業, 67, 721-728
    2016/10
    [Journal page]

  32. Site-Specific Control of Multiple Mineralizations Using a Designed Peptide and DNA
    Kenji Usui*, Makoto Ozaki, Aoi Yamada, Yoshio Hamada, Takaaki Tsuruoka, Takahito Imai, Kin-ya Tomizaki
    Nanoscale, 8, 17081-17084 ※中裏表紙掲載
    DOI: 10.1039/c6nr03468c
    2016/08
    [Journal page] [PubMed] [Inside back cover]

  33. Site-Specific Control of Silica Mineralization on DNA Using a Designed Peptide
    Makoto Ozaki, Kazuma Nagai, Hiroto Nishiyama, Takaaki Tsuruoka, Satoshi Fujii, Tamaki Endoh, Takahito Imai, Kin-ya Tomizaki, Kenji Usui*
    Chem. Commun., 52, 4010-4013 ※中裏表紙掲載
    DOI: 10.1039/c5cc07870a
    2016/03
    [Journal page] [PubMed] [Inside back cover]

  34. A Cell Microarray Format: A Peptide Release System Using a Photo-Cleavable Linker for Cell Toxicity and Cell Uptake Analysis
    Kenji Usui*, Kin-ya Tomizaki, Hisakazu Mihara
    Methods. Mol. Biol., 1352, 199-210
    DOI: 10.1007/978-1-4939-3037-1_15
    [Journal page] [PubMed]
  35. 先頭へ


    2015

  36. 生体分子解析・細胞解析に向けた設計ペプチドチップ
    臼井健二*、堤浩、三原久和
    バイオチップの基礎と応用, 143-152
    [Journal page]

  37. Label and Label-Free Detection Techniques for Protein Microarrays
    Amir Syahir, Kenji Usui*, Kin-ya Tomizaki, Kotaro Kajikawa, Hisakazu Mihara
    Microarrays, 4, 228-244
    DOI: 10.3390/microarrays4020228
    2015/04
    [Journal page] [PubMed]

  38. Control of Guanine-Rich DNA Secondary Structures Depending on the Protease Activity Using a Designed PNA Peptide
    Kenji Usui*, Arisa Okada, Keita Kobayashi, Naoki Sugimoto
    Org. Biomol. Chem., 13, 2022-2025
    DOI: 10.1039/c4ob02535k
    2015/02
    [Journal page] [PubMed]

  39. ATP-Binding Peptide-Hydrogel Composite Synthesized by Molecular Imprinting on Beads
    Ayana Takata, Kenji Usui, Jun Matsui
    Molecular Imprinting, 3, 65-70
    [Journal page]
  40. 先頭へ


    2014

  41. Cellular Differentiation Assessments by Measuring the Degree of Cellular Internalization and Membrane Adsorption Using Designed Peptides.
    Kenji Usui*, Takuya Kikuchi, Kunio Kikuchi, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
    Bioorg. Med. Chem. lett., 24, 4129-4131
    DOI: 10.1016/j.bmcl.2014.07.053
    2014/09
    [Journal page] [PubMed]

  42. Peptides Targeting G-Quadruplex Structures
    Arisa Okada, Kenji Usui*
    Chemical Biology of Nucleic Acids:Fundamentals and Clinical Applications, 459-475
    [Journal page]
  43. 先頭へ


    2013

  44. A Novel Array Format for Monitoring Cellular Uptake Using a Photo-Cleavable Linker for Peptide Release
    Kenji Usui*, Takuya. Kikuchi, Kin-ya Tomizaki, Takashi Kakiyama, Hisakazu Mihara
    Chem. Commun., 49, 6394-6396
    DOI: 10.1039/c3cc41632a
    2013/07
    [Journal page] [PubMed]

  45. Systematic Screening of the Cellular Uptake of Designed Alpha-Helix Peptides
    Kenji Usui*, Takuya. Kikuchi, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
    Bioorg. Med. Chem., 21, 2560-2567
    DOI: 10.1016/j.bmc.2013.02.030
    2013/05
    [Journal page] [PubMed]

  46. A Peptide Release System Using a Photo-Cleavable Linker in a Cell Array Format for Cell-Toxicity Analysis
    Takashi Kakiyama, Kenji Usui*, Kin-ya Tomizaki, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
    Polym J., 45, 535-539
    [Journal page] [Pubmed]
  47. 先頭へ


    2012

  48. “オミクス”研究に向けた設計ペプチドアレイの構築
    臼井健二、富崎欣也、三原久和
    分析化学 , 61, 523-534
    [Journal page]
  49. 先頭へ


    2011

  50. Use of a Designed Peptide Library to Screen for Binders to a Particular DNA G-Quadruplex Sequence
    Keita Kobayashi, Noriko Matsui, Kenji Usui*
    J. Nucleic Acids , 2011:572873
    DOI: 10.4061/2011/572873
    [Journal page] [PubMed]

  51. Cell Fingerprint Patterns Using Designed α-Helical Peptides to Screen for Cell-Specific Toxicity
    Kenji Usui, Takashi Kakiyama, Kin-ya Tomizaki, Masayasu Mie, Eiry Kobatake, Hisakazu Mihara
    Bioorg. Med. Chem. Lett., 21, 6281-6284
    DOI: 10.1016/j.bmcl.2011.09.002
    2011/11
    [Journal page] [PubMed]

  52. Thermodynamic Stability of Hoogsteen and Watson-Crick Base Pairs in the Presence of Histone H3-Mimicking Peptide
    Smritimoy Pramanik, Kaori Nakamura, Kenji Usui, Shu-ichi Nakano, Sarika Saxena, Jun Matsui, Daisuke Miyoshi, Naoki Sugimoto
    Chem. Commun., 47, 3967-3971
    DOI: 10.1039/c0cc05776b
    2011/03
    [Journal page] [PubMed]
  53. 先頭へ


    2010

  54. Protein-protein Interactions and Selection: Array-Based Techniques for Screening Disease-Associated Biomarkers in Predictive/Early Diagnosis
    Kin-ya Tomizaki, Kenji Usui, Hisakazu Mihara
    FEBS J., 277, 1996-2005
    DOI: 10.1111/j.1742-4658.2010.07626.x.
    2010/05
    [Journal page] [PDF] [PubMed]

  55. 第10章 デザインペプチドを用いたプロテインアレイと細胞アレイ
    臼井健二、富崎欣也、三原久和
    化学フロンティア22 生命現象を理解する分子ツール、(化学同人)、79-87
    2010/09
    [HP]
  56. 先頭へ


    2009

  57. Site-Specific Modification of Alzheimer's Peptides by Cholesterol Oxidation Products Enhances Aggregation Energetics and Neurotoxicity
    Kenji Usui, John D. Hulleman, Johan F. Paulsson, Sarah J. Siegel, Evan T. Powers, Jeffery W. Kelly
    Proc. Natl. Acad. Sci. USA, 106, 18563-18568
    DOI: 10.1073/pnas.0804758106
    2009/11
    [Journal page] [PDF] [PubMed]

  58. A Designed Peptide Chip: Protein Fingerprinting Technology with a Dry Peptide Array and Statistical Data Mining
    Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
    Methods. Mol. Biol., 570, 273-284
    DOI: 10.1007/978-1-60327-394-7_13
    [Journal page] [PubMed]

  59. Proteins: Array-Based Techniques
    Kin-ya Tomizaki, Kenji Usui, Hisakazu Mihara
    Wiley Encyclopedia of Chemical Biology, 4, 144-158
    DOI: 10.1002/9780470048672.wecb022
    [Journal page]

  60. プロテインチップデバイス
    臼井健二・富崎欣也・三原久和
    超分子サイエンス&テクノロジー、(エヌ・ティー・エス)、1067-1075
    2009/05
    [HP]

  61. タンパク質・細胞分析用デザインペプチドチップ
    臼井健二・菊池卓哉・三原久和
    シングルセル解析の最前線、(シーエムシー出版)、17-24
    [HP]
  62. 先頭へ


    2007

  63. Screening of Alpha-Helical Peptide Ligands Controlling a Calcineurin-Phosphatase Activity
    Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
    Bioorg. Med. Chem. Lett., 17, 167-171
    DOI: 10.1016/j.bmcl.2006.09.075
    2007/01
    [Journal page] [PubMed]

  64. Interactions between Peptides Containing Nucleobase Amino Acids and T7 Phages Displaying S. Cerevisiae Proteins
    Sinya Watanabe, Kin-ya Tomizaki, Tsuyoshi Takahashi, Kenji Usui, Kotaro Kajikawa, Hisakazu Mihara
    Biopolymers, 88, 131-140
    DOI: 10.1002/bip.20662
    [Journal page] [PubMed]

  65. ペプチドライブラリを用いるタンパク質相互作用検出チップ
    富崎欣也・臼井健二・三原久和
    Electrochemistry, 75, 981-985
    [Journal page] [CiNii]
  66. 先頭へ


    2006

  67. Protein-Fingerprint Data Mining of a Designed Alpha-Helical Peptide Array
    Kenji Usui, Kin-ya Tomizaki, Hisakazu Mihara
    Mol. BioSyst., 2, 417-420 ※表紙掲載
    2006/09
    [Journal page] [PubMed]

  68. A Novel Peptide Microarray for Protein Detection and Analysis Utilizing a Dry Peptide Array System
    Kenji Usui, Kin-ya Tomizaki, Takafumi Ohyama, Kiyoshi Nokihara, Hisakazu Mihara
    Mol. BioSyst., 2, 113-121
    DOI: 10.1039/b514263f
    2006/02
    [Journal page] [PubMed]

  69. A PNA-DNA Hybridization Chip Approach for the Detection of Beta-Secretase Activity
    Shusuke Sano, Kin-ya Tomizaki, Kenji Usui, Hisakazu Mihara
    Bioorg. Med. Chem. Lett., 16, 503-506
    DOI: 10.1016/j.bmcl.2005.10.064
    2006/02
    [Journal page] [PubMed]
  70. 先頭へ


    2005

  71. A Designed Glycopeptide Array for Characterization of Sugar-Binding Proteins toward a Glycopeptide Chip Technology
    Kenji Usui, Tetsunori Ojima, Kin-ya Tomizaki, Hisakazu Mihara
    Nanobiotechnology, 1, 191-200
    [Journal page]

  72. IR Study on Stacking Manner of Peptide Nanorings in Peptide Nanotubes
    Yukiko Nagai, Tsutomu Nakanishi, Hajime Okamoto, Kyozaburo Takeda, Yukio Furukawa, Kenji Usui, Hisakazu Mihara
    Jpn. J. Appl. Phys., 44, 7654-7661
    [Journal page]

  73. Difference in Self-Assembling Morphology of Peptide Nanorings
    Hajime Okamoto, Tetsuo Yamada, Hiroshi Miyazaki, Tsutomu Nakanishi, Kyozaburo Takeda, Kenji Usui,Ikuo Obataya, Hisakazu Mihara, Hiroaki Azehara, Wataru Mizutani, Katsushi Hashimoto, Hiroshi Yamaguchi, Yoshiro Hirayama
    Jpn. J. Appl. Phys., 44, 8240-8248
    [Journal page]

  74. Anomalous Reflection of Gold Applicable for a Practical Protein-Detecting Chip Platform
    Sinya Watanabe, Kenji Usui, Kin-ya Tomizaki, Kotaro Kajikawa, Hisakazu Mihara
    Mol. BioSyst., 1, 363-365
    DOI: 10.1039/b513075c
    2005/12
    [Journal page] [PubMed]

  75. Protein-Detecting Microarrays: Current Accomplishments and Requirements
    Kin-ya Tomizaki, Kenji Usui, Hisakazu Mihara
    ChemBioChem, 6, 782-799 ※表紙掲載
    DOI: 10.1002/cbic.200400232
    2005/05
    [Journal page] [PubMed]
  76. 先頭へ


    2004

  77. Peptide Arrays with Designed Alpha-Helical Structures for Characterization of Proteins from FRET-Fingerprint Patterns
    Kenji Usui, Mizuki Takahashi, Kiyoshi Nokihara, Hisakazu Mihara
    Mol. Divers., 8, 209-218
    [Journal page] [PubMed]

  78. Peptide Arrays with Designed Secondary Structures for Protein Characterization Using Fluorescent Fingerprint Patterns
    Kenji Usui, Tetsunori Ojima, Mizuki Takahashi, Kiyoshi Nokihara, Hisakazu Mihara
    Biopolymers, 76, 129-139
    DOI: 10.1002/bip.10568
    [Journal page] [PubMed]

  79. ペプチドアレイを用いたプロテインチップの実用化を目指した研究
    軒原清史・大山貴史・臼井健二・米村耕一・富崎欣也・三原久和
    高分子論文集61、523-532
    [PDF] [CiNii]

  80. Development of Peptide-Chips Focusing on a High Throughput Protein-Detection System
    Kiyoshi Nokihara, Takafumi Ohyama, Kenji Usui, Koichi. Yoneyama, Mizuki Takahashi, Hisakazu Mihara
    Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries, 83-88
  81. 先頭へ


    2003

  82. プロテインチップ
    臼井健二・三原久和
    化学装置2003年4月号、36-38
    [Journal page]

  83. ペプチドマイクロアレイ ~ペプチドライブラリを用いた新規プロテインチップの創製~
    臼井健二・三原久和
    Bioベンチャー 2003年7・8月号3, 99-102
    [Journal page]
  84. 先頭へ

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