We have developed a method for predicting the intracellular stability of RNA/DNA hybrid double strands that can forecast the efficacy of nucleic acid therapeutics and genome editing.
Dr. Dipanwita Banerjee, Postdoctoral Fellow; Associate Professor Hisae Tateishi-Karimata; Director and Professor Naoki Sugimoto of Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, in collaboration with a research group led by Professor Janez Plavec at Slovenian NMR Centre, have developed a method for predicting the intracellular stability of RNA/DNA hybrid double strands that can be utilized in the design of nucleic acid therapeutics targeting various diseases and in improving the efficiency of genome editing. This research was published in the Journal of the American Chemical Society (J. Am. Chem. Soc.) (Impact Factor = 16.383) in October 2023.
This research was conducted as part of this project (Core-to-core Project), with Professor Plavec of Slovenian NMR Centre serving as the representative of the Slovenian research institution. The research in Slovenia is supported by Central European Research Infrastructure Consortium. The consortium has issued a press release highlighting these findings as groundbreaking research results.
Press Release from Central European Research Infrastructure Consortium
We will continue to contribute to the advancement of science and technology and to society through research findings in the field of biochemistry.
（Published Article）
In-Cell Stability Prediction of RNA/DNA Hybrid Duplexes for Designing Oligonucleotides Aimed at Therapeutics
Dipanwita Banerjee, Hisae Tateishi-Karimata, Maria Toplishek, Tatsuya Ohyama, Saptarshi Ghosh, Shuntaro Takahashi, Marko Trajkovski, Janez Plavec, and Naoki Sugimoto*
J. Am. Chem. Soc. 145, 23503–23518 (2023)
https://pubs.acs.org/doi/10.1021/jacs.3c06706?ref=pdf
