2023年

• Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments
  

  Torii T, Sugimoto W, Itoh K, Kinoshita N, Gessho M , Goto T, Uehara I, Nakajima W, Budirahardja Y, Miyoshi D, Nishikata T, Tanaka N, Hirata H, Kawauchi K
  Cell Death & Disease (2023) 14, Article number: 766

• The iron chelator deferriferrichrysin induces paraptosis via extracellular-signal-regulated kinase activation in cancer cells.
  

  Kinoshita N, Gessho M, Torii T, Ashida T, Akamatsu M, Guo AK, Lee S,Katsuno T, Nakajima W, Budirahardja Y, Miyoshi D, Todokoro T, Ishida H, Nishikata T, Kawauchi K
  Genes to Cells (2023) https://doi.org/10.1111/gtc.13053

• Biomolecular Liquid–Liquid Phase Separation for Biotechnology
  

  Shil S, Tsuruta M, Kawauchi K, Miyoshi D
  BioTech, 12(2), 26 (2023)

• Simple and fast screening for structure-selective G-quadruplex ligands
  Hashimoto Y, Imagawa Y, Nagano K, Maeda R, Nagahama N, Torii T, Kinoshita N, Takamiya N, Kawauchi K, Tateishi-Karimata H, Sugimoto N, Miyoshi D
  Chemical Communications (back front cover), 59, 4891-4894(2023)

2022年

• 細胞内環境で安定化される核酸非構造を狙った分子標的薬の開発

  川内敬子、橋本佳樹、杉本渉、三好大輔
  バイオマテルアルー生体材料ー(ISSN1347-7080),40(3),6pages(2022)

• Photodynamic therapy targeting nucleic acid G-quadruplexes
  

  Torii T, Kinoshita N, Urano R, Miyoshi D, Kawauchi K
  Journal of the Society of Japanese Women Scientists, vol. 22, 25-35; DOI 10.5939/sjws.22006 (2022)

• Controlling liquid–liquid phase separation of G-quadruplex-forming RNAs in a sequence-specific manner
  Tsuruta T, Torii T, Kazuki Kohata, Kawauchi K,Tateishi-Karimata H, Sugimoto N , Miyoshi D
  Chemical Communications 2022,58, 12931-12934
• rDNAおよびrRNAが形成する四重らせん構造による核小体機能の制御
  川内敬子、取井猛流、月生雅也、木下菜月、三好大輔
  月刊細胞 2022年 11月号
• 核酸の四重らせん構造を狙った治療薬の展望
  木下菜月, 取井猛流, 川内敬子,三好大輔
  Bio Clinina 2022年 4月号

• Intramolecular G-quadruplex-hairpin loop structure competition of a GC rich exon region in the TMPRESS2 gene
  Sugimoto W, Kinoshita N, Nakata M, Ohyama T, Tateishi-Karimata H, Nishikata T, Sugimoto N, Miyoshi D, Kawauch K.
  Chemical Communications 2022, issue 1

2021年

• Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells
  Dobrokhotov O, Sunagawa M, Torii T, Mii S, Kawauch K, Enomoto A, Sokabe M, Hirata H.
  Frontiers in Cell and Developmental Biology. 11 November 2021

2020年

• Photosensitizers Based on G-quadruplex Ligand for Cancer Photodynamic therapy
  Kawauch K, Urano R, Kinoshita K, Kuwamoto S, Torii T, Hashimoto Y, Taniguchi S, Tsuruta M, Miyoshi D.
  Genes 2020, 11(11),1340

• Novel Strategy of Photodynamic Therapy Targeting RAS mRNA with G-Quadruplex Ligands for Cancer Treatment
  Torii T, Sugimoto W, Kawauchi K , Miyosi D
  Journal of Data Mining in Genomics & Proteomics 2020, 11, 2
• MMP24 as a Target of YAP Is a Potential Prognostic Factor in Cancer Patients
  Sugimoto W, Itoh K, Hirata H, Abe Y, Torii T, Mitsui Y, Budirahardja Y, Tanaka N, Kawauchi K
  Bioengineering 2020, 7 (1), 18
  

2019年

• The RAS mRNA G-quadruplex:making undruggable cancer targets druggable
  Kawauchi K, Miyoshi D,Sugimoto W.
  ATRAS of Science. October 8, 2019
  

• Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity
  Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald FL, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y
  Science Advances 25 Sep 2019 : Vol. 5, no. 9, eaau 7802. DOI: 10.1126/sciadv.aau7802
  
• DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death
  Itoh K, Ebata T, Hirata H, Torii T, Sugimoto W, Onodera K, Nakajima W, Uehara I, Okuzaki D, Yamauchi S, Budirahardja Y, Nishikata T, Tanaka N, Kawauchi K
  Molecules. 24(17), 3175 (2019)
• Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells
  Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, Ohtani K
  Comnunications Biology. 2, 3 (2019)

2018年

• An anionic phthalocyanine decrease NRAS expression by breaking down its RNA G-quadruplex
  Kawauchi K, Sugimoto W, Yasui T, Murata K, Itoh K, Tsuruoka T, Akamatsu K, Tateishi H, Sugimoto N, Miyoshi D
  Nature commun. 9, 2271 (2018)

• Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering　
  Nagahama K, Oyama N, Ono K, Hotta A, Kawauchi K, Nishikata T.
  Biomater Sci. 6, 550-561 (2018)

• Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription
  Tateishi-Karimata H, Kawauchi K, Sugimoto N
  J Am Chem Soc. 140, 642-651 (2018)

• Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2
  Sugimoto W, Itoh K, Mitsui Y, Ebata T, Fujita H, Hirata H, Kawauchi K
  Cell Adhesion & Migration.12 (2018) doi: 10.1080/19336918.2017.1338233.

2017年

• NF-kB prevents oncogenic Ras-induced β-actin cleavage in p53-deficient cells
  Sugimoto W, Itoh K, Kotari T, Alvin Kunyao Guo, Ebata T, Hirata H, Kawauchi K
  Int J Cancer Cell Biol Res 2, 14-18 (2017)

• Cell and Molecular Mechanics in Health and Disease
  Kawauchi K, Fujita H, Miyoshi D, Yim EK, Hirata H
  Biomed Res Int, 2017, 2860241 (2017)

• Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression
  Ebata T, Mitsui Y, Sugimoto W, Maeda M, Araki K, Machiyama H, Harada I, Sawada Y, Fujita H, Hirata H, Kawauchi K
  BioMed Res Int, 2017, 5158961 (2017)

2016年

• MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility
  Hirata H, Ku WC, Yip AK, Ursekar CP, Kawauchi K, Roy A, Guo AK, Vedula SR, Harada I, Chiam KH, Ishihama Y, Lim CT, Sawada Y, Sokabe M
  J Cell Sci, 129, 3574-3582 (2016)

• Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling
  Ebata T, Hirata H, Kawauchi K
  Biomed Res Int, 2016, 9231057 (2016)

• Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration
  Zhao Z, Tan SH, Machiyama H, Kawauchi K, Araki K, Hirata H, Sawada Y
  Biol Open, 5, 499-506 (2016)

2015年

• p53 regulates cytoskeleton remodeling to suppress tumor progression
  Araki K, Ebata T, Guo AK, Tobiume K, Wolf SJ, Kawauchi K
  Cell Mol Life Sci, 72, 4077-4094 (2015)

• Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope
  Shao X, Kawauchi K, Shivashankar GV, Bershadsky AD
  Biol Open, 4, 1569-1575 (2015)

• Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force
  Yu CH, Rafiq NB, Cao F, Zhou Y, Krishnasamy A, Biswas KH, Ravasio A, Chen Z, Wang YH, Kawauchi K, Jones GE, Sheetz MP
  Nat Commun, 6, 8672 (2015)

2014年

• Understanding p53: new insights into tumor suppression
  Kawauchi K, Wolf SJ
  Expert Rev Anticancer Ther, 14, 1101-1103 (2014)

• Displacement of p130Cas from focal adhesions links actomyosin contraction to cell migration
  Machiyama H, Hirata H, Loh XK, Kanchi MM, Fujita H, Tan SH, Kawauchi K, Sawada Y
  J Cell Sci, 127, 3440-3450 (2014)

• Culturing of mouse and human cells on soft substrates promote the expression of stem cell markers
  Higuchi S, Watanabe TM, Kawauchi K, Ichimura T, Fujita H
  J Biosci Bioeng, 117, 749-755 (2014)

• Loss of p53 enhances NF-κB-dependent lamellipodia formation
  Guo AK, Hou YY, Hirata H, Yamauchi S, Yip AK, Chiam KH, Tanaka N, Sawada Y, Kawauchi K
  J Cell Physiol, 229, 696-704 (2014)

• p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion
  Yamauchi S, Hou YY, Guo AK, Hirata H, Nakajima W, Yip AK, Yu CH, Harada I, Chiam KH, Sawada Y, Tanaka N, Kawauchi K
  J Cell Biol, 204, 1191-1207 (2014)

2013年以前

• Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization
  Araki K, Kawauchi K, Hirata H, Yamamoto M, Taya Y
  Elife, e01228 (2013)

• Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis
  Yamauchi S, Kawauchi K, Sawada Y
  FEBS Lett, 586, 3229?3235 (2012)

• p130 Cas-dependent actin remodelling regulates myogenic differentiation
  Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y
  Biochem J, 445, 323-332 (2012)

• Chromatin plasticity as a differentiation index during muscle differentiation of C2C12 myoblasts
  Watanabe TM, Higuchi S, Kawauchi K, Tsukasaki Y, Ichimura T, Fujita H
  Biochem Biophys Res Commun, 418, 742-747 (2012)

• Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3
  Ando M, Uehara I, Kogure K, Asano Y, Nakajima W, Abe Y, Kawauchi K, Tanaka N
  J Nippon Med Sch, 77, 97-105 (2010)

• The molecular mechanism of glucose metabolism hampered by p53 tumor suppressor protein
  Kawauchi K
  J Nippon Med Sch, 77, 48-49 (2010)

• Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification
  Kawauchi K, Araki K, Tobiume K, Tanaka N
  Proc Natl Acad Sci USA, 106, 3431?3436 (2009)

• Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation
  Kawauchi K, Araki K, Tobiume K, Tanaka N
  Biochem Miophys Res Commun, 372, 137-141 (2008)

• Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells
  Kawauchi K, Tobiume K, Iwashita K, Inagaki H, Morikawa T, Shibukawa Y, Moriyama Y, Hirata H, Kamata H
  Biosci Biotechnol Biochem, 72, 1564-1570 (2008)

• IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors
  Araki K, Kawauchi K, Tanaka N
  Oncogene, 27, 5696-5705 (2008)

• p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
  Kawauchi K, Araki K, Tobiume K, Tanaka N
  Nat Cell Biol, 10, 611-618 (2008)

• Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
  Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N
  Proc Natl Acad Sci USA, 105, 4838-4843 (2008)

• Suppression of AP-1 activity by cycloprodigiosin hydrochloride
  Kawauchi K, Tobiume K, Kaneko S, Kaneshiro K, Okamoto S, Ueda E, Kamata H, Moriyama Y, Hirata H
  Biol Pharm Bull, 30, 1792-1795 (2007)

• Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor
  Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K
  Biochemistry, 44, 3891-3898 (2005)

• Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta
  Teshima S, Nakanishi H, Kamata K, Kaibori M, Kwon AH, Kamiyama Y, Nishizawa M, Ito S, Okumura T
  Nitric Oxide, 11, 9-16 (2004)

• Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation
  Kyo S, Sada K, Qu X, Maeno K, Miah SM, Kawauchi-Kamata K, Yamamura H
  Genes Cells, 8, 825-836 (2003)

• Adaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase
  Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K
  J Biol Chem, 278, 24912-24920 (2003)

• Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops
  Kamata H, Manabe T, Oka Si, Kamata K, Hirata H
  FEBS Letters, 519, 231-237 (2002)

• Synergistic effects induced by cycloprodigiosin hydrochloride and epirubicin on human breast cancer cellsYamamoto D, Tanaka K, Nakai K, Baden T, Inoue K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Morikawa S, Inubushi T, Hioki K
  Breast Cancer Research and Treatment, 72, 1-10 (2002)

• Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB
  Kamata K, Okamoto S, Oka S, Kamata H, Yagisawa H, Hirata H
  FEBS Letters, 507, 50774-50780 (2001)

• Cycloprodigiosin hydrochloride, a H+/Cl- symporter, induces apoptosis in human colon cancer cell lines in vitroYamamoto C, Takemoto H, Kuno K, Yamamoto D, Nakai K, Baden T, Kamata K, Hirata H, Watanabe T, Inoue KOncology Reports, 8, 821-824 (2001)

• Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cellsYamamoto D, Uemura Y, Tanaka K, Nakai K, Yamamoto C, Takemoto H, Kamata K, Hirata H, Hioki KInternational Journal of Cancer, 88, 121-128 (2000)

• Demonstration of Cl- requirement for inhibition of vacuolar acidification by cycloprodigiosin in situ
  Nakayasu T, Kawauchi K, Hirata H, Shimmen T
  Plant & Cell Physiol, 41, 857-863 (2000)

• N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases
  Oka S, Kamata H, Kamata K, Yagisawa H, Hirata H
  FEBS Letters, 472, 196-202 (2000)

• Cycloprodigiosin hydrochloride, a new H(+)/Cl(-) symporter, induces apoptosis in human and rat hepatocellular cancer cell lines in vitro and inhibits the growth of hepatocellular carcinoma xenografts in nude mice
  Yamamoto C, Takemoto H, Kuno K, Yamamoto D, Tsubura A, Kamata K, Hirata H, Yamamoto A, Kano H, Seki T, Inoue K
  Hepatology, 30, 894-902 (1999)

• Cycloprodigiosin uncouples H+-pyrophosphatase of plant vacuolar membranes in the presence of chloride ionMaeshima, M, Nakayasu, T, Kawauchi, K, Hirata, H, Shimmen, T
  Plant & Cell Physiol, 40, 439-442 (1999)

• Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent
  Kim HS, Hayashi M, Shibata Y, Wataya Y, Mitamura T, Horii T, Kawauchi K, Hirata H, Tsuboi S, Moriyama Y
  Biol. Pharm. Bull, 22, 532-534 (1999)

• Cycloprodigiosin hydrochloride inhibits acidification of plant vacuole
  Nakayasu T, Kawauchi K, Hirata H, Shimmen T
  Plant & Cell Physiol, 40, 143-148 (1999)

• A possible immunosuppressant, cycloprodigiosin hydrochloride, obtained from Pseudoalteromonas denitrificans
  Kawauchi K, Shibutani K, Yagisawa H, Kamata H, Nakatsuji S, Anzai H, Yokoyama Y, Ikegami Y, Moriyama Y, Hirata H
  Biochem. Biophys. Res. Commun, 237, 543-547 (1997)

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著書

• 三好大輔、川内敬子
  相分離生物学の全貌　担当；DNA・RNAと相分離　現代化学増刊（東京化学同人）19-24（2020））

• 杉本渉、川内敬子、三好大輔　
  メディカル・サイエンス・ダイジェスト　RNAサイレシングと疾患 2020年p26-27
  RASmRNAを狙った分子標的型光線力学療法

• ゼロからはじまるバイオ実験マスターコース３―細胞培養トレーニング (秀潤社)
  西方敬人、川上純司、藤井敏司、長濱宏治、川内敬子

• 大野茂男、千葉奈津子、川内敬子、駒田雅之、山本陽一朗、宮川隆、小原英幹、野島博、芳賀永、下野洋平、博夫、北爪しのぶ、佐谷秀行　
  がん研究分野の特性等を踏まえた支援活動総括支援活動班編がん研究読本6 2016年p29-37
  RASによるがん悪性化に、p53を介したアクチン細胞骨格の変化がブレーキをかける道筋を解明！