公表論文


研究室から公表した論文(2009年度以降)

2022

R. Morimoto, M. Horita, D. Yamaguchi, H. Nakai, and S. Nakano
Evaluation of weak interactions of proteins and organic cations with DNA duplex structures
Biophys. J., 121, 2873-2881 (2022)

2021

中野修一
核酸医薬の配列設計のためのin vitro評価:細胞内物質との弱い相互作用の影響 [In Japanese]
BIO Clinica(北隆館)、12(36)、82-84 (2021)

S. Nakano, H. Yamashita, and N. Sugimoto
Enhancement of the catalytic activity of hammerhead ribozymes by organic cations
ChemBioChem, 22, 2721-2728 (2021)

2020

中野修一
第II部 14. リボザイム [In Japanese]
核酸化学ハンドブック、杉本直己 編(講談社サイエンティフィック)、426-429 (2020)

中野修一
細胞の内部環境は核酸医薬に用いられるオリゴヌクレオチドにどのような影響を与えるか [In Japanese]
月刊細胞(ニューサイエンス社)、52(5)、42-44 (2020)

2019

S. Nakano, H. Yamashita, K. Tanabe, and N. Sugimoto
Bulky cations greatly increase the turnover of a native hammerhead ribozyme
RSC Advances, 9, 35820-35824 (2019)

S. Nakano, T. Ayusawa, Y. Tanino, and N. Sugimoto
Stabilization of DNA loop structures by large cations
J. Phys. Chem. B, 123, 7687-7694 (2019)

中野修一・杉本直己
分子夾雑環境が制御する核酸分子の機能 [In Japanese]
化学と工業、72、401-403(2019)

2018

S. Nakano, D. Yamaguchi, and N. Sugimoto
Thermal stability and conformation of DNA and proteins under the confined condition in the matrix of hydrogels
Mol. Biol. Rep., 45, 403-411 (2018)

2017

S. Nakano, M. Horita, M. Kobayashi, and N. Sugimoto
Catalytic activities of ribozymes and DNAzymes in water and mixed aqueous media
Catalysis, 7 (Special issue: Homogeneous Catalysis and Mechanisms in Water and Biphasic Media), 355-348 (2017)

S. Nakano, T. Watabe, and N. Sugimoto
Modulation of the ribozyme and deoxyribozyme activities using tetraalkylammonium ions
ChemPhysChem, 18, 3614-3619 (2017)

2016

S. Nakano and N. Sugimoto
Model studies of the effects of intracellular crowding on nucleic acid interactions
Mol. BioSyst., 13, 32-41 (2016)

S. Nakano, Y. Tanino, H. Hirayama, and N. Sugimoto
Thermal stability of RNA structures with bulky cations in mixed aqueous solutions
Biophys. J., 111, 1350-1360 (2016)

S. Nakano, H. Oka, M. Fujii, and N. Sugimoto
Use of a ureido-substituted deoxycytidine module for DNA assemblies
Nucleosides, Nucleotides and Nucleic Acids, 35, 370-378 (2016)

S. Nakano and N. Sugimoto
The structural stability and catalytic activity of DNA and RNA oligonucleotides in the presence of organic solvents
Biophys. Rev., 8, 11-23 (2016)

2015

S. Nakano, Y. Kitagawa, D. Miyoshi, and N. Sugimoto
Effects of background anionic compounds on the activity of the hammerhead ribozyme in Mg2+
J. Biol. Inorg. Chem., 20, 1049-1058 (2015)

S. Nakano, Y. Kitagawa, H. Yamashita, D. Miyoshi, and N. Sugimoto
Effects of cosolvents on the folding and catalytic activities of the hammerhead ribozyme
ChemBioChem, 16, 1803-1810 (2015)

2014

S. Nakano, M. Yoshida, D. Yamaguchi, and N. Sugimoto
Preparation of hydrogels for the study of the effects of spatial confinement on DNA
Trans. Mat. Res. Soc. Jpn., 39, 435-438 (2014)

S. Nakano and N. Sugimoto
Roles of the amino group of purine bases in the thermodynamic stability of DNA base pairing
Molecules, 19, 11613-11627 (2014)

S. Nakano, Y. Kitagawa, D. Miyoshi, and N. Sugimoto
Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds
FEBS Open Bio, 4, 643–650 (2014)

S. Nakano, D. Miyoshi, and N. Sugimoto
Effects of molecular crowding on the structures, interactions, and functions of nucleic acids
Chem. Rev., 114, 2733-2758 (2014)

2013

S. Nakano, Y. Uotani, Y. Sato, H. Oka, M. Fujii, and N. Sugimoto
Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication
Nucleic Acids Res., 41, 8581-8590 (2013)

2012

S. Nakano, H. Oka, D. Yamaguchi, M. Fujii, and N. Sugimoto
Base-pairing selectivity of a ureido-linked phenyl-2′-deoxycytidine derivative
Org. Biomol. Chem., 10, 9664-9670 (2012)

S. Nakano, H. Hirayama, D. Miyoshi, and N. Sugimoto
Dimerization of nucleic acid hairpins in the conditions caused by neutral cosolutes
J. Phys. Chem. B, 116, 7406-7415 (2012)

S. Nakano, D. Yamaguchi, H. Tateishi-Karimata, D. Miyoshi, and N. Sugimoto
Hydration changes upon DNA folding studied by osmotic stress experiments
Biophys. J., 102, 2808-2817 (2012)

2011

S. Nakano, T. Kanzaki, M. Nakano, D. Miyoshi, and N. Sugimoto
Measurements of the binding of a large protein using a substrate density-controlled DNA chip
Anal. Chem., 83, 6368-6372 (2011)

S. Nakano, M. Fujii, and N. Sugimoto
Use of nucleic acid analogs for the study of nucleic acid interactions
J. Nucleic Acids, 2011, Article ID 967098, 11 pages (2011)

2010

S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Stacking interaction in the middle and at the end of a DNA helix studied with non-natural nucleotides
Mol. BioSyst., 6, 2023-2029 (2010)

A. Rajendran, S. Nakano, and N. Sugimoto
Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH
Chem. Commun., 46, 1299-1301 (2010)

中野修一・杉本直己
化学ツールとしての分子クラウディング [In Japanese]
化学フロンティア 生命現象を理解する分子ツール最前線〜イメージングから生体機能解析まで〜、浜地格・二木史朗 編(化学同人)、145-153 (2010)

中野修一・杉本直己
生体シグナル解析用の機能性核酸センサーの定量的デザイン [In Japanese]
シングルセル解析の最前線, 神原秀記・松永是・植田充美 監修(シーエムシー出版)、9-16 (2010)

杉本直己・中野修一
第一節 DNAチップの基礎1 ハイブリダイゼーション [In Japanese]
バイオチップ実用化ハンドブック, 金子周一・堀池靖浩 監修(エヌティーエス)、13-19 (2010)

2009

S. Nakano, H. Tateishi-Karimata, Y. Kitagawa, and N. Sugimoto
Facilitation of RNA enzyme activity in the molecular crowding media of cosolutes
J. Am. Chem. Soc., 131, 16881–16888 (2009)

S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides
Biochemistry, 48, 11304-11311 (2009)

S. Nakano and N. Sugimoto
Energy of nucleic acid self-assemblies: From sequence to function through structure
Bottom-up Nanofabrication: Supramolecules, Self-Assemblies, and Organized Films, K. Ariga and H. S. Nalwa eds. (American Scientific Publishers), Vol. 3, 191-215 (2009)