教員

中野 修一 (Shu-ichi Nakano)

甲南大学フロンティアサイエンス学部 教授

教員・研究者詳細
補助金研究報告

TEL: 078-303-1429
E-mail: shuichi (at) konan-u.ac.jp

〒650-0047 兵庫県神戸市中央区港島南町7 –1–20
甲南大学フロンティアサイエンス学部生命化学科

担当講義:生命物理化学、バイオ計測工学、数学及び演習、ナノバイオラボベーシック、ナノバイオラボ、ベーシックキャリアデザイン、理系キャリアデザイン など


公表論文

126
R. Morimoto, M. Horita, D. Yamaguchi, H. Nakai, and S. Nakano
Evaluation of weak interactions of proteins and organic cations with DNA duplex structures
Biophys. J., 121, 2873-2881 (2022)

125
中野修一
核酸医薬の配列設計のためのin vitro評価:細胞内物質との弱い相互作用の影響 [In Japanese]
BIO Clinica(北隆館)、12(36)、82-84 (2021)

124
S. Nakano, H. Yamashita, and N. Sugimoto
Enhancement of the catalytic activity of hammerhead ribozymes by organic cations
ChemBioChem, 22, 2721-2728 (2021)

123
K. Akamatsu, S. Nakano, K. Kimura, Y. Takashima, T. Tsuruoka, H. Nawafune, Y. Sato, J. Murai, and H. Yanagimoto
Controlling interfacial ion-transport kinetics using polyelectrolyte membranes for additive- and effluent-free, high-performance electrodeposition
ACS Appl. Mater. Interfaces, 13, 13896-13906 (2021)

122
中野修一
第II部 14. リボザイム [In Japanese]
核酸化学ハンドブック、杉本直己 編(講談社サイエンティフィック)、426-429 (2020)

121
中野修一
細胞の内部環境は核酸医薬に用いられるオリゴヌクレオチドにどのような影響を与えるか [In Japanese]
月刊細胞(ニューサイエンス社)、52(5)、42-44 (2020)

120
H. Tateishi-Karimata, D. Banerjee, T. Ohyama, S. Matsumoto, D. Miyoshi, S. Nakano, and N. Sugimoto
Hydroxyl groups in cosolutes regulate the G-quadruplex topology of telomeric DNA
Biochem. Biophys. Res. Commun., 525, 177-183 (2020)

119
S. Nakano, H. Yamashita, K. Tanabe, and N. Sugimoto
Bulky cations greatly increase the turnover of a native hammerhead ribozyme
RSC Advances, 9, 35820-35824 (2019)

118
S. Nakano, T. Ayusawa, Y. Tanino, and N. Sugimoto
Stabilization of DNA loop structures by large cations
J. Phys. Chem. B, 123, 7687-7694 (2019)

117
中野修一・杉本直己
分子夾雑環境が制御する核酸分子の機能 [In Japanese]
化学と工業、72、401-403(2019)

116
S. Nakano, D. Yamaguchi, and N. Sugimoto
Thermal stability and conformation of DNA and proteins under the confined condition in the matrix of hydrogels
Mol. Biol. Rep., 45, 403-411 (2018)

115
S. Nakano, M. Horita, M. Kobayashi, and N. Sugimoto
Catalytic activities of ribozymes and DNAzymes in water and mixed aqueous media
Catalysis, 7 (Special issue: Homogeneous Catalysis and Mechanisms in Water and Biphasic Media), 355-348 (2017)

114
K. Usui, A. Okada, S. Sakashita, M. Shimooka, T. Tsuruoka, S. Nakano, D. Miyoshi, T. Mashima, M. Katahira, and Y. Hamada
DNA G-wire formation using an artificial peptide is controlled by protease activity
Molecules, 22, 1991-2002 (2017)

113
S. Nakano, T. Watabe, and N. Sugimoto
Modulation of the ribozyme and deoxyribozyme activities using tetraalkylammonium ions
ChemPhysChem, 18, 3614-3619 (2017)

112
H. Tateishi-Karimata, T. Ohyama, T. Muraoka, P. Podbevsek, A. M. Wawro, S. Tanaka, S. Nakano, K. Kinbara, J. Plavec, and N. Sugimoto
Newly characterized interaction stabilizes DNA structure: oligoethylene glycols stabilize G-quadruplexes CH-pi interactions
Nucleic Acid Res., 45, 7021-7030 (2017)

111
S. Nakano and N. Sugimoto
Model studies of the effects of intracellular crowding on nucleic acid interactions
Mol. BioSyst., 13, 32-41 (2016)

110
Y. Ueda, Y. Zouzumi, A. Maruyama, S. Nakano, N. Sugimoto, and D. Miyoshi
Effects of trimethylamine N-oxide and urea on DNA duplex and G-quadruplex
Sci. Tech. Adv. Mat.,17, 753-759 (2016)

109
S. Nakano, Y. Tanino, H. Hirayama, and N. Sugimoto
Thermal stability of RNA structures with bulky cations in mixed aqueous solutions
Biophys. J., 111, 1350-1360 (2016)

108
M. Nakano, H. Tateishi-Karimata, S. Tanaka, F. Tamab, O. Miyashita, S. Nakano, and N. Sugimoto
Local thermodynamics of the water molecules around single- and double-stranded DNA studied by grid inhomogeneous solvation theory
Chem. Phys. Lett., 660, 250-255 (2016)

107
S. Nakano, H. Oka, M. Fujii, and N. Sugimoto
Use of a ureido-substituted deoxycytidine module for DNA assemblies
Nucleosides, Nucleotides and Nucleic Acids, 35, 370-378 (2016)

106
M. Yamaguchi, Y. Zouzumi, N. Shimada, S. Nakano, N. Sugimoto, A. Maruyama, and D. Miyoshi
A reversible B-A transition of DNA duplexes induced by synthetic cationic copolymers
Chem. Commun., 52, 7446-7449 (2016)

105
S. Nakano and N. Sugimoto
The structural stability and catalytic activity of DNA and RNA oligonucleotides in the presence of organic solvents
Biophys. Rev., 8, 11-23 (2016)

104
M. Nakano, H. Tateishi-Karimata, S. Tanaka, F. Tama, O. Miyashita, S. Nakano, and N. Sugimoto
Thermodynamic properties of water molecules in the presence of cosolute depend on DNA structure: a study using grid inhomogeneous solvation theory
Nucleic Acids Res., 43, 10114-10125 (2015)

103
S. Nakano, Y. Kitagawa, D. Miyoshi, and N. Sugimoto
Effects of background anionic compounds on the activity of the hammerhead ribozyme in Mg2+-unsaturated solutions
J. Biol. Inorg. Chem., 20, 1049-1058 (2015)

102
S. Nakano, Y. Kitagawa, H. Yamashita, D. Miyoshi, and N. Sugimoto
Effects of cosolvents on the folding and catalytic activities of the hammerhead ribozyme
ChemBioChem, 16, 1803-1810 (2015)

101
S. Nakano, M. Yoshida, D. Yamaguchi, and N. Sugimoto
Preparation of hydrogels for the study of the effects of spatial confinement on DNA
Trans. Mat. Res. Soc. Jpn., 39, 435-438 (2014)

100
S. Nakano and N. Sugimoto
Roles of the amino group of purine bases in the thermodynamic stability of DNA base pairing
Molecules, 19, 11613-11627 (2014)

99
D. Miyoshi, Y. Ueda, N. Shimada, S. Nakano, N. Sugimoto, and A. Maruyama
Drastic stabilization of parallel DNA hybridizations by a polylysine comb-type copolymer with hydrophilic graft chain
ChemMedChem, 9 (Special Issue: DNA & RNA Medicinal Chemistry), 2156-2163(2014)

98
H. Tateishi-Karimata, S. Pramanik, S. Nakano, D. Miyoshi, and N. Sugimoto
Dangling ends perturb the stability of RNA duplexes responsive to surrounding conditions
ChemMedChem, 9 (Special Issue: DNA & RNA Medicinal Chemistry), 2150-2155 (2014)

97
S. Nakano, Y. Kitagawa, D. Miyoshi, and N. Sugimoto
Hammerhead ribozyme activity and oligonucleotide duplex stability in mixed solutions of water and organic compounds
FEBS Open Bio, 4, 643–650 (2014)

96
S. Nakano, D. Miyoshi, and N. Sugimoto
Effects of molecular crowding on the structures, interactions, and functions of nucleic acids
Chem. Rev., 114, 2733-2758 (2014)

95
S. Nakano, Y. Uotani, Y. Sato, H. Oka, M. Fujii, and N. Sugimoto
Conformational changes of the phenyl and naphthyl isocyanate-DNA adducts during DNA replication and by minor groove binding molecules
Nucleic Acids Res., 41, 8581-8590 (2013)

94
H. Yaku, T. Murashima, H. Tateishi-Karimata, S. Nakano, D. Miyoshi, and N. Sugimoto
Study on effects of molecular crowding on G-quadruplex-ligand binding and ligand-mediated telomerase inhibition
Methods, 64, 19-27 (2013)

93
H. Tateishi-Karimata, S. Nakano, and N. Sugimoto
Quantitative analyses of nucleic acid stability under the molecular crowding condition induced by cosolute
Curr. Protoc. Nucleic Acid Chem., Chap. 53, Unit 7.19 (2013)

92
T. Fujimoto, S. Nakano, N. Sugimoto, and D. Miyoshi
Thermodynamics-hydration relationships within loops that affect G-quadruplexes under molecular crowding conditions
J. Phys. Chem. B, 117, 963-972 (2013)

91
S. Nakano, H. Oka, D. Yamaguchi, M. Fujii, and N. Sugimoto
Base-pairing selectivity of a ureido-linked phenyl-2′-deoxycytidine derivative
Org. Biomol. Chem., 10, 9664-9670 (2012)

90
H. Yu, X. Gu, S. Nakano, D. Miyoshi, and N. Sugimoto
The beads-on-a-string structure of long telomeric DNAs under molecular crowding conditions
J. Am. Chem. Soc., 134, 20060-20069 (2012)

89
K. Akamatsu, M. Fujii, T. Tsuruoka, S. Nakano, T. Murashima, and H. Nawafune
Mechanistic study on microstructural tuning of metal nanoparticle/polymer composite thin layers: Hydrogenation and decomposition of polyimide matrices catalyzed by embedded nickel nanoparticles
J. Phys. Chem. C, 116, 17947–17954 (2012)

88
S. Nakano, H. Hirayama, D. Miyoshi, and N. Sugimoto
Dimerization of nucleic acid hairpins in the conditions caused by neutral cosolutes
J. Phys. Chem. B, 116, 7406-7415 (2012)

87
S. Nakano, D. Yamaguchi, H. Tateishi-Karimata, D. Miyoshi, and N. Sugimoto
Hydration changes upon DNA folding studied by osmotic stress experiments
Biophys. J., 102, 2808-2817 (2012)

86
S. Nakano, T. Kanzaki, M. Nakano, D. Miyoshi, and N. Sugimoto
Measurements of the binding of a large protein using a substrate density-controlled DNA chip
Anal. Chem., 83, 6368-6372 (2011)

85
S. Nakano, M. Fujii, and N. Sugimoto
Use of nucleic acid analogs for the study of nucleic acid interactions
J. Nucleic Acids, 2011, Article ID 967098, 11 pages (2011)

84
T. Fujimoto, S. Nakano, D. Miyoshi, and N. Sugimoto
The effects of molecular crowding on the structure and stability of G-quadruplexes with an abasic site
J. Nucleic Acids, 2011, Article ID 857149, 9 pages (2011)

83
J. Bhattacharyya, S. Maiti, S. Muhuri, S. Nakano, D. Miyoshi, and N. Sugimoto
Effect of locked nucleic acid modifications on the thermal stability of noncanonical DNA structure
Biochemistry, 50, 7414–7425 (2011)

82
S. Pramanik, K. Nakamura, K. Usui, S. Nakano, S. Saxena, J. Matsui, D. Miyoshi and N. Sugimoto
Thermodynamic stability of Hoogsteen and Watson-Crick base pairs in the presence of histone H3-mimicking peptide
Chem. Commun., 47, 2790-2792 (2011)

81
S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Stacking interaction in the middle and at the end of a DNA helix studied with non-natural nucleotides
Mol. BioSyst., 6, 2023-2029 (2010)

80
A. Rajendran, S. Nakano, and N. Sugimoto
Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH
Chem. Commun., 46, 1299-1301 (2010)

79
中野修一・杉本直己
化学ツールとしての分子クラウディング [In Japanese]
化学フロンティア 生命現象を理解する分子ツール最前線〜イメージングから生体機能解析まで〜、浜地格・二木史朗 編(化学同人)、145-153 (2010)

78
中野修一・杉本直己
生体シグナル解析用の機能性核酸センサーの定量的デザイン [In Japanese]
シングルセル解析の最前線, 神原秀記・松永是・植田充美 監修(シーエムシー出版)、9-16 (2010)

77
杉本直己・中野修一
第一節 DNAチップの基礎1 ハイブリダイゼーション [In Japanese]
バイオチップ実用化ハンドブック, 金子周一・堀池靖浩 監修(エヌティーエス)、13-19 (2010)

76
S. Nakano, H. Tateishi-Karimata, Y. Kitagawa, and N. Sugimoto
Facilitation of RNA enzyme activity in the molecular crowding media of cosolutes
J. Am. Chem. Soc., 131, 16881–16888 (2009)

75
S. Nakano, H. Oka, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides
Biochemistry, 48, 11304-11311 (2009)

74
S. Nakano and N. Sugimoto
Energy of nucleic acid self-assemblies: From sequence to function through structure
Bottom-up Nanofabrication: Supramolecules, Self-Assemblies, and Organized Films, K. Ariga and H. S. Nalwa eds. (American Scientific Publishers), Vol. 3, 191-215 (2009)

73
H. Kanno, S. Nakano, A. Kubo, T. Mimura, N. Tajima, and N. Sugimoto
Neuronal differentiation of neural progenitor cells by intracellular delivery of synthetic oligopeptide derived from von Hippel-Lindau protein
Protein & Peptide Lett., 16, 1291-1296 (2009)

72
S. Nakano, H. Hirayama, and N. Sugimoto
Investigation of the cation binding to nucleotides by monitoring the hairpin-duplex equilibrium of a self-complementary sequence
Nucleic Acids Symp. Ser., 53, 519-520 (2009)

71
S. Nakano, L. Wu, H. Oka, H. T. Karimata, T. Kirihata, Y. Sato, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, and N. Sugimoto
Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media
Mol. BioSyst., 4 (Emerging investigators issue), 579-588 (2008)

70
S. Nakano, T. Kirihata, and N. Sugimoto
Capture of cationic ligands bound diffusely to base pairs during the DNA refolding
Chem. Commun., 700-702 (2008)

69
H. Yaku, T. Yukimasa, S. Nakano, N. Sugimoto, and H. Oka
Design of allele-specific primers and detection of the human ABO genotyping to avoid the pseudopositive problem
Electrophoresis, 29, 4130-4140 (2008)

68
S. Nakano, Y. Kitagawa, H. T. Karimata, and N. Sugimoto
Molecular crowding effect on metal ion binding properties of the hammerhead ribozyme
Nucleic Acids Symp. Ser., 52, 519-520 (2008)

67
杉本直己・中野修一
DNAはなぜ二重らせん構造になるのか? —分子間相互作用と分子環境効果を考えるー [In Japanese]
現代化学(東京化学同人)、Vol. 450 (No.9), 25-30 (2008)

66
S. Nakano, T. Kirihata, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, and N. Sugimoto
Influence of cationic molecules on the hairpin to duplex equilibria of self-complementary DNA and RNA oligonucleotides
Nucleic Acids Res., 35, 486-494 (2007)

65
S. Nakano and P. C. Bevilacqua
Mechanistic characterization of the HDV genomic ribozyme: A mutant of the C41 motif provides insight into positioning and thermodynamic linkage of metal ions and protons
Biochemistry, 46, 3001-3012 (2007)

64
X. Gu, S. Nakano, and N. Sugimoto
Consecutive GC base pairs determine the energy barrier of DNA duplex formation under molecularly crowded conditions
Chem. Commun., 2750-2752 (2007)

63
H. Karimata, S. Nakano, and N. Sugimoto
Effects of polyethylene glycol on a DNA duplex stability differed by the NaCl concentration
Bull. Chem. Soc. Jpn., 80, 1987-1994 (2007)

62
H. Oka, S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Functionalization of DNA by the base pair-mimic nucleosides
Nucleic Acids Symp. Ser., 51, 151-152 (2007)

61
S. Nakano, K. Uenishi, M. Fujii, and N. Sugimoto
The base-pairing ability of the base pair-mimic nucleosides
Nucleic Acids Symp. Ser., 51, 71-72 (2007)

60
K. Akamatsu, M. Kimura, Y. Shibata, S. Nakano, D. Miyoshi, H. Nawafune, and N. Sugimoto
A DNA duplex with extremely enhanced thermal stability based on controlled immobilization on gold nanoparticles
Nano Lett., 3, 491-495 (2006)

59
S. Nakano, Y. Uotani, Y. Sato, H. Oka, K. Uenishi, M. Fujii, and N. Sugimoto
Recognition of the base pair-mimic nucleosides by DNA polymerases
Nucleic Acids Symp. Ser., 50, 201-202 (2006)

58
X.-B. Gu, S. Nakano, and N. Sugimoto
The effect of the structure of cosolutes on the DNA duplex formation
Nucleic Acids Symp. Ser., 50, 205-206 (2006)

57
H. Karimata, S. Nakano, and N. Sugimoto
The roles of cosolutes on the hammerhead ribozyme activity
Nucleic Acids Symp. Ser., 50, 81-82 (2006)

56
中野修一・杉本直己
分子クラウディング環境は生命分子の物性と機能をいかに変えるか [In Japanese]
生物物理(日本生物物理学会)、Vol. 46 (No.5), 251-256 (2006)

55
杉本直己・中野修一・大道達雄
デザイナブル核酸修飾 [In Japanese]
遺伝子医学MOOK5 先端生物医学研究・医療のため遺伝子導入テクノロジー「ウイルスを用いない遺伝子導入法の材料、技術、方法論の新たな展開」, 原島秀吉・田畑泰彦 編(メディカルドゥ)、245-251 (2006)

54
杉本直己・中野修一
細胞の分子クラウディング効果 [In Japanese]
現代化学(東京化学同人)、Vol. 428 (No.11), 53-58 (2006)

53
S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
Site-selective RNA cleavage by DNA bearing a base pair-mimic nucleoside
J. Am. Chem. Soc., 127, 518-519 (2005)

52
S. Nakano, Y. Uotani, K. Uenishi, M. Fujii, and N. Sugimoto
DNA base flipping by a base pair-mimic nucleoside
Nucleic Acids Res., 33, 7111-7119 (2005)

51
S. Nakano and N. Sugimoto
Central dogma for a molecular design based on DNA: DNB (databasing/designable nanobio) ENB (engineering nanobio) FNB (functional nanobio)
Chem. Lett., 34, 1206-1211 (2005)

50
P. C. Bevilacqua, T. S. Brown, D. Chadalavada, J. Lecomte, E. Moody, and S. Nakano
Linkage between proton binding and folding in RNA: implications for RNA catalysis
Biochem. Soc. Trans., 33, 466-470 (2005)

49
T. Kirihata, S. Nakano, S. Fujii, M. Matsumoto, M. Kuwahara, H. Sawai, and N. Sugimoto
Conformational switch of oligonucleotides induced by spermine
Nucleic Acids Symp. Ser., 49, 241-242 (2005)

48
S. Nakano, H. Karimata, T. Ohmichi, J. Kawakami, and N. Sugimoto
The effect of molecular crowding with nucleotide length and cosolute structure on DNA duplex stability
J. Am. Chem. Soc., 126, 14330-14331 (2004)

47
S. Nakano, T. Kanzaki, and N. Sugimoto
Influences of ribonucleotide on a duplex conformation and its thermal stability: Study with the chimeric RNA-DNA strands
J. Am. Chem. Soc., 126, 1088-1095 (2004)

46
D. Miyoshi, S. Matsumura, S. Nakano, and N. Sugimoto
Duplex dissociation of telomere DNAs induced by molecular crowding
J. Am. Chem. Soc., 126, 165-169 (2004)

45
P. C. Bevilacqua, T. S. Brown, S. Nakano, and R. Yajima
Catalytic roles for proton transfer and protonation in ribozymes: Current understanding and future possibilities
Biopolymers, 73, 90-109 (2004)

44
S. Nakano, Y. Uotani, Y. Anno, M. Fujii, and N. Sugimoto
Conformational change of a nucleotide by a base-pair mimic nucleoside in the complementary DNA strand
Nucleic Acids Symp. Ser., 48, 259-260 (2004)

43
H. Karimata, S. Nakano, T. Ohmichi, J. Kawakami, and N. Sugimoto
Stabilization of a DNA duplex under molecular crowding conditions of PEG
Nucleic Acids Symp. Ser., 48, 107-108 (2004)

42
T. Kirihata, S. Nakano, and N. Sugimoto
Secondary structure change of oligonucleotides induced by salts
Nucleic Acids Symp. Ser., 48, 109-110 (2004)

41
S. Nakano and N. Sugimoto
An oligopeptide containing the C-terminal sequence of RNase A has a potent RNase A binding property
J. Am. Chem. Soc., 125, 8728-8729 (2003)

40
S. Nakano, Y. Uotani, S. Nakashima, Y. Anno, M. Fujii, and N. Sugimoto
Large stabilization of a DNA duplex by the deoxyadenosine derivatives tethering an aromatic hydrocarbon group
J. Am. Chem. Soc., 125, 8086-8087 (2003)

39
S. Nakano, A. L. Cerrone, and P. C. Bevilacqua
Mechanistic characterization of the HDV genomic ribozyme: Classifying the catalytic and structural metal ion sites within a multichannel reaction mechanism
Biochemistry, 42, 2982-2994 (2003)

38
W. Li, D. Miyoshi, S. Nakano, and N. Sugimoto
Structural competition involving G-quadruplex DNA and its complement
Biochemistry, 42, 11736-11744 (2003)

37
Y. Okumoto, H. Fujiki, J. Kawakami, S. Nakashima, S. Nakano, T. Ohmichi, D. Miyoshi, and N. Sugimoto
Novel biomaterials derived from deoxyribozyme and napzyme
Macromol. Symp., 201, 245-252 (2003)

36
Y. Uotani, S. Nakano, S. Nakashima, Y. Anno. M. Fujii, and N. Sugimoto
Large stacking stability of a base pair-mimic nucleotide on the DNA duplex
Nucleic Acids Res. Supple., 3, 79-80 (2003)

35
S. Nakano, Y. Uotani, and N. Sugimoto
An oligopeptide containing the C-terminal sequence of RNase A inhibits an RNA hydrolysis by RNase A
First Int. Symp. Biomol. Chem., 240-241 (2003)

34
S. Nakano and N. Sugimoto
Important effects of non-Watson-Crick interactions and cation binding on nucleic acid structures
Research Development in Nucleosides and Nucleotides (Transworld Research Network), Vol. 1, 59-80 (2003)

33
中野修一・杉本直己
タンパク質に人工分子を結合させる新手法 [In Japanese]
Bio Medical Quick Review Net(メディカルドゥ)、記事番号005 (2003)

32
杉本直己・中野修一
遺伝子の正体:DNAとRNA [In Japanese]
化学と教育(日本化学会)、Vol. 51 (No. 7), 398-401 (2003)

31
T. Ohmichi, S. Nakano, D. Miyoshi, and N. Sugimoto
Long RNA dangling end has large energetic contribution to duplex stability
J. Am. Chem. Soc., 124, 10367-10372 (2002)

30
P. Wu, S. Nakano, and N. Sugimoto
Temperature dependence of thermodynamic properties for DNA/DNA and RNA/DNA duplex formation
Eur. J. Biochem., 269, 2821-2830 (2002)

29
T. Kanzaki, S. Nakano, and N. Sugimot
Role of 2'-OH on thermodynamic stability and structure of chimeric oligonucleotides
Nucleic Acids Res. Supple., 2, 189-190 (2002)

28
中野修一・杉本直己
「生命を化学する」・・・生命科学のすすめ 生命現象を化学に活用する [In Japanese]
化学(化学同人)、Vol. 57 (No. 11), 42-47 (2002)

27
中野修一・杉本直己
「生命を化学する」・・・小分子で巨大タンパク質の挙動を操る タンパク質のドメイン・スワッピングとその制御 [In Japanese]
化学(化学同人)、Vol. 57 (No. 8), 42-47 (2002)

26
杉本直己・中野修一
核酸の相互作用 [In Japanese]
化学フロンティア5 生命化学のニューセントラルドグマ テーラーメイド・バイオケミストリーのめざすもの, 杉本直己 編(化学同人)、24-34 (2002)

25
S. Nakano and P. C. Bevilacqua
Proton inventory of the genomic HDV ribozyme in Mg2+-containing solutions
J. Am. Chem. Soc., 123, 11333-11334 (2001)

24
S. Nakano, D. J. Proctor, and P. C. Bevilacqua
Mechanistic characterization of the HDV genomic ribozyme: Assessing the catalytic and structural contributions of divalent metal ions within a multichannel reaction mechanism
Biochemistry, 40, 12022-12038 (2001)

23
N. Sugimoto, N. Satoh, K. Yasuda, and S. Nakano
Stabilization factors affecting duplex formation of peptide nucleic acid with DNA
Biochemistry, 40, 8444-8451 (2001)

22
杉本直己・中野修一
核酸における超ワトソン・クリックモデルの試み カチオンと非ワトソン・クリック型塩基の役割を考える [In Japanese]
化学と生物(日本農芸化学会)、Vol. 39 (No. 11), 714-722 (2001)

21
S. Nakano, D. M. Chadalavada, and P. C. Bevilacqua
General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
Science, 287, 1493-1497 (2000)

20
D. M. Chadalavada, S. M. Knudsen, S. Nakano, and P. C. Bevilacqua
A role for upstream RNA structure in facilitating the catalytic fold of the genomic hepatitis delta virus ribozyme
J. Mol. Biol., 301, 349-367 (2000)

19
N. Sugimoto, M. Nakano, and S. Nakano
Thermodynamics-structure relationship of single mismatches in RNA/DNA duplexes
Biochemistry, 39, 11270-11281 (2000)

18
C. Nakamura, Y. Inuyama, K. Shirai, S. Nakano, N. Sugimoto, and J. Miyake
Analysis for peptide binding to porphyrin using surface plasmon resonance
Synthetic Metals, 117, 127-129 (2000)

17
S. Nakano, M. Fujimoto, H. Hara, and N. Sugimoto
Nucleic acid duplex stability: Influence of base composition on cation effects
Nucleic Acids Res., 27, 2957-2965 (1999)

16
中野修一
核酸の安定性と、RecAタンパク質由来のペプチドによる一本鎖核酸の認識に関する研究 [In Japanese]
学位論文 (1999)

15
S. Nakano and N. Sugimoto
Single-stranded DNA recognition of a 24 mer peptide derived from RecA protein
Bull. Chem. Soc. Jpn., 71, 2205-2210 (1998)

14
N. Sugimoto and S. Nakano
Effect of cation concentration on duplex stability of nucleic acids with unnatural base pairs
Nucleic Acids Symp. Ser., 39, 121-122 (1998)

13
杉本直己・中野修一
タンパク質の機能を担う低分子ペプチド 化学で生物活性を再現する [In Japanese]
化学(化学同人)、Vol. 53 (No. 6), 40-44 (1998)

12
N. Sugimoto and S. Nakano
A 24 mer peptide derived from RecA protein can discriminate a single-stranded DNA from a double-stranded DNA
Chem. Commun., 2125-2126 (1997)

11
N. Sugimoto and S. Nakano
Sandwiching interaction of peptides with a porphyrin
Chem. Lett., 939-940 (1997)

10
N. Sugimoto, S. Nakano, and M. Fujimoto
Experimental quantitation of cation effect on nucleic acid stability
Nucleic Acids Symp. Ser., 37, 147-148 (1997)

9
N. Sugimoto and S. Nakano
A 24 mer peptide with activity of a nucleic acid discrimination and its recombination
First Int. Peptide Symp., P-108 (1997)

8
N. Sugimoto, S. Nakano, M. Yoneyama, and K. Honda
Improved thermodynamic parameters and helix initiation factor to predict stability of DNA duplexes
Nucleic Acids Res., 24, 4501-4505 (1996)

7
N. Sugimoto, S. Nakano, M. Katoh, M. Sasaki, and S. Kugimiya
Interactions of 5-(1-pyrenyl)-10,15,20,-tris(4-methyl-pyridinium)porphine with double-helix and triple-helix nucleic acids
Nucleosides & Nucleotides, 15, 743-747 (1996)

6
N. Sugimoto and S. Nakano
Development of new SPR chip with an oligopeptide recognizing a single-stranded DNA
Nucleic Acids Symp. Ser., 35, 303-304 (1996)

5
N. Sugimoto, S. Nakano, M. Katoh, A. Matsumura, H. Nakamuta, T. Ohmichi, M. Yoneyama, and M. Sasaki
Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes
Biochemistry, 34, 11211-11216 (1995)

4
N. Sugimoto, S. Nakano, M. Yoneyama, H. Nakamuta, T. Ohmichi, and M. Sasaki
Thermodynamic stability of RNA/DNA hybrids
J. Biomol. Struct. Dyn., 12, a233 (1995)

3
S. Nakano, M. Sasaki, and N. Sugimoto
Interaction of oligonuleotides with a single stranded DNA binding site of RecA protein
Nucleic Acids Symp. Ser., 34, 61-62 (1995)

2
杉本直己・中野修一・米山麻里・佐々木宗夫
核酸の機能と構造に関する微視的相互作用 XI –DNAの一本鎖部位の安定性とペプチド認識における役割 [In Japanese]
甲南大学紀要理学部編、Vol. 42, 37-41 (1995)

1
N. Sugimoto, M. Katoh, S. Nakano, T. Ohmichi, and M. Sasaki
RNA/DNA hybrid duplexes with identical nearest-neighbor base-pairs have identical stability
FEBS Lett., 354, 74-78 (1994)